ABSTRACT. – Cluj-Napoca Urban Growth from 1250 to 2012. A Geographical Information System Approach. This paper presents a study of urban growth in Cluj-Napoca city, Romania, by using Geographical Information Systems (GIS), historical maps, historical evidences and General Urbanistic Plans. The study explores the temporal and spatial characteristics of urban expansion from 1250 to 2012, and population dynamic from 1450 to 2012. Overlapping the layers obtained by digitizing the cartographic materials, a map representing Cluj-Napoca urban growth dynamics for 1250- 2012 period was realized. The economic development, the migration flows from village to city and other activities, have resulted in the increase of urbanization and therefore in substantial changes in the population structure.